What is neuroaxonal dystrophy?
This is a slowly progressive disorder in which swellings (spheroids) develop and accumulate along axons throughout the brain and spinal cord. Axons are the parts of the nerve cells along which impulses travel, and so this condition results in abnormal conduction of nervous impulses, and associated clinical signs such as a high-stepping gait and lack of coordination.
How is neuroaxonal dystrophy inherited?
Inheritance is believed to be autosomal recessive.
What breeds are affected by neuroaxonal dystrophy?
This condition is seen in the rottweiler. A similar disorder has been seen sporadically in dogs of a few other breeds.
For many breeds and many disorders, the studies to determine the mode of inheritance or the frequency in the breed have not been carried out, or are inconclusive. We have listed breeds for which there is a consensus among those investigating in this field and among veterinary practitioners, that the condition is significant in this breed.
What does neuroaxonal dystrophy mean to your dog & you?
Clinical signs are usually first noticed around a year of age, although owners of affected dogs may feel that their puppy was unusually clumsy. Signs seen with this disorder include an awkward or high-stepping gait, poor coordination, and development of a head tremor, all of which gradually worsen over several years. Dogs do not lose their strength over this time.
How is neuroaxonal dystrophy diagnosed?
Diagnosis is made based on breed (rottweiler), clinical signs, and the absence of abnormalities on other diagnostic tests.
For the veterinarian: There is slowly progressive ataxia of all 4 limbs, without paresis or loss of conscious proprioception (in contrast to rottweiler leukodystrophy) even when the signs become severe. Positional nystagmus, decreased menace response, crossed extensor reflexes, and exaggerated patellar reflexes are also seen. Other reflexes remain normal.
How is neuroaxonal dystrophy treated?
There is no treatment. However because the disorder progresses slowly, affected dogs can often function acceptably for many years.
Affected dogs and their parents (carriers of the trait) should not be bred. The breeding of siblings (suspect carriers) should also be avoided. Unfortunately, due to its slowly progressive nature, the condition may not be diagnosed until breeding has already occurred.
FOR MORE INFORMATION ABOUT THIS DISORDER, PLEASE SEE YOUR VETERINARIAN.
Ackerman, L. 1999. The Genetic Condition: A Guide to Health Problems in Purebred Dogs. pp 140-141. AAHA Press. Lakewood, Colorado.
LeCouteur, R.A., Child, G. 1995. Diseases of the spinal cord. In S.J. Ettinger and E.C. Feldman (eds.) Textbook of Veterinary Internal Medicine, p. 629-696. W.B. Saunders Co., Toronto.
March, P.A. 1996. Degenerative brain disease. Vet. Clin. of N.A. Small Animal Practice. 26(4): 945-971.
Copyright © 1998 Canine Inherited Disorders Database. All rights reserved.
Revised: October 30, 2001.This database is a joint initiative of the Sir James Dunn Animal Welfare Centre at the Atlantic Veterinary College, University of Prince Edward Island, and the Canadian Veterinary Medical Association.