What is acral mutilation syndrome?
This is a bizarre syndrome in which dogs lose pain sensation in their toes. This is due to abnormal development and slowly progressive degeneration after birth of the sensory neurons in the spinal cord and in peripheral nerves.
Affected dogs initially chew at their feet but eventually will do extensive damage.
How is acral mutilation syndrome inherited?
This condition is believed to be autosomal recessive.
What breeds are affected by acral mutilation syndrome?
This occurs in the German short-haired pointer and English pointer.
For many breeds and many disorders, the studies to determine the mode of inheritance or the frequency in the breed have not been carried out, or are inconclusive. We have listed breeds for which there is a consensus among those investigating in this field and among veterinary practitioners, that the condition is significant in this breed.
What does acral mutilation syndrome mean to your dog & you?
Affected pups usually begin to bite and lick their feet at 3 to 5 months of age, and have no temperature or pain sensation in the toes and sometimes up the legs. The hind legs are most severely affected.
Your dog's toes and feet will become swollen and ulcerated. S/he will continue to walk without any apparent discomfort on the mutilated feet.
Unfortunately attempts to prevent further mutilation are generally unsuccessful.
How is acral mutilation syndrome diagnosed?
The diagnosis can usually be made based on distinctive clinical signs in a young dog of a typical breed. More than one pup in a litter may be affected. Electromyography will give a definitive diagnosis by revealing an absence of normal nerve potentials in your dog.
Diagnosis can also be made at necropsy, based on the characteristic changes in the nervous system.
For the veterinarian: These dogs have paronychia and may have autoamputation of the toes. Proprioception is normal, other reflexes are intact. EMG shows no denervation potentials.
How is acral mutilation syndrome treated?
Unfortunately there is no treatment. Attempts to prevent mutilation through the use of bandages, collars or sedation are unsuccessful and, as the mutilation worsens, owners generally request euthanasia.
There is no test for carriers of this disorder. Parents and siblings of affected dogs should not be used for breeding.
FOR MORE INFORMATION ABOUT THIS DISORDER, PLEASE SEE YOUR VETERINARIAN.
Scott, D.W., Miller, W.H., Griffin, C.E. 1995. Muller and Kirk's Small Animal Dermatology. p 799. W.B. Saunders Co., Toronto.
Copyright © 1998 Canine Inherited Disorders Database. All rights reserved.
Revised: October 30, 2001.This database is funded jointly by the Sir James Dunn Animal Welfare Centre at the Atlantic Veterinary College, University of Prince Edward Island, and the Canadian Veterinary Medical Association.