Rare red blood cell abnormalities
Pyruvate kinase deficiency and phosphofructokinase deficiency are two clinically important red blood cell disorders that are discussed elsewhere in this database.
The disorders listed below are associated with abnormalities of the red blood cells. Most of these abnormalities will have no impact on your dog's health but may show up during blood tests. They are listed here mainly for the information of veterinarians . These disorders are all very rare.
Abnormality Breeds affected (RARE) Special tests Clinical features glucose-6-phophate dehydrogenase deficiency Weimaraner G6PD activity reduced none high potassium erythrocytes Akita increased rbc and serum potassium none, pseudohyperkalemia familial microcytosis Akita microcytosis none familial macrocytosis and dyshematopoiesis miniature and toy poodle macrocytosis none (gingivitis) familial nonspherocytic hemolytic anemia beagle reticulocytosis none to mild anemia congenital methemoglobinemia several breeds determination of methemoglobin usually none other than cyanotic-appearing tongue/mucous membranes selective cobalamin malabsorption giant schnauzer low serum cobalamin (B12) moderate anemia, cachexia, dementia, respond to administration of B12 familial nonspherocytic hemolytic anemia poodle none, PCV 10-25% hemolytic anemia, osteosclerosis stomatocytosis Alaskan malamute, miniature Schnauzer increased fragility of stomatocytes chondrodysplasia in malamutes For many breeds and many disorders, the studies to determine the mode of inheritance or the frequency in the breed have not been carried out, or are inconclusive. The above disorders are seen very rarely in veterinary medicine and, where studies have been carried out, this is usually because of a similarity to a condition in people.
Giger, U., Smith,B.F., Rajpurohit, W.P. 1992. Inherited erhythrocyte disorders. ACVIM- Proceedings of the 10th Annual Veterinary Medical Forum:142-145.
Harvey, J.W. 1995. Congenital hemolytic anemias and methemoglobinemias. ACVIM-Proceedings of the 13th Annual Veterinary Medical Forum:37-40.
Copyright © 1998 Canine Inherited Disorders Database. All rights reserved.
Revised: October 30, 2001.This database is funded jointly by the Animal Welfare Unit at the Atlantic Veterinary College, University of Prince Edward Island, and the Canadian Veterinary Medical Association.