Welcome to the publication list.
Here is a list of the publications of the Linkletter Research
Group. They are available in Adobe Acrobat ".PDF"
format and an external link is given to the actual journal
article on the publisher's web site where applicable.
Refereed Publications
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Solid-Phase Synthesis of Oligopurine Deoxynucleic
Guanidine (DNG) and Analysis of Binding with DNA Oligomers.
Linkletter, B.; Szabo, I.E.; Bruice. T.C. Nucl. Acids
Res. Dec. 2001, 29, 2370-2376
PDF version 
Publisher's Site
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Solid-phase Synthesis of Positively Charged Deoxynucleic
Guanidine (DNG) Modified Oligonucleotides Containing
Neutral Urea Linkages. Effect of Charge Deletions on
Binding and Fidelity.
Linkletter, B.; Bruice, T.C.. Bioorg. Med. Chem.
2000, 1893-1901.
PDF version (388
K)
Publisher's Site
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Rapid Hydrolysis of 2’,3’-cAMP with a
Cu(II) Complex: Effect of Intramolecular Hydrogen Bonding
on the Basicity and Reactivity of a Metal-Bound Hydroxide.
Wall, W.; Linkletter, B.; Williams, D.; Lebuis, A.-M.;
Hynes, R.C.; Chin, J. J. Am. Chem. Soc. 1999,
121, 4710-4711.
PDF version (48
K)
Publisher's Site
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Solid-Phase Synthesis of Deoxynucleic Guanidine
(DNG) Oligomers and Melting Point and Circular Dichroism
Analysis of Binding Fidelity of Octameric Thymidyl Oligomers
with DNA Oligomers.
Barry A. Linkletter, Istvan E. Szabo, and Thomas C.
Bruice
Journal of the American Chemical Society, 1999,
121, 3888-96
PDF version (152
K)
Publisher's Site
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Synthesis of Protected Guanidinium Linked Dinucleoside
Incorporable Into an Oligonucleotide Using Solid Phase
DNA Methodology.
Dinesh A. Barawkar, Barry Linkletter, and Thomas C.
Bruice
Bioorganic & Medicinal Chemistry Letters, 1998,
8, 1517-20.
PDF version (268
K)
Publisher's Site
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Solid-Phase Synthesis of Oligomeric Deoxynucleic
Guanidine (DNG): A Polycationic Analogue of DNA.
Barry A. Linkletter and Thomas C. Bruice
Bioorganic & Medicinal Chemistry Letters, 1998,
8, 1285-90.
PDF version (436
K)
Publisher's Site
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Rapid Hydrolysis of RNA with a Cu Complex.
Linkletter B; Chin J.
Angewandte Chemie-International Edition In English,
1995, 34, 472-474.
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Benzylchlorocarbene - UV Absorption Spectrum, Kinetics
For 1,2-H Migration and Mechanism For Reaction With
Acetic Acid as Determined by Combined Continuous and
Laser-Flash Photolysis.
Bonneau R.; Liu M.T.H.; Subramanian R.; Linkletter B.;
et. al..
Laser Chemistry, 1990, 10, 267-275.
Conference Presentations
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Solid-Phase Synthesis of Oligopurine Deoxynucleic
Guanidine (DNG) and Analysis of Binding with DNA Oligomers.
Studies Toward a New Antisense Therapeutic Agent.
Oral presentation at the 84th Canadian Society for
Chemistry Conference & Exhibition, Montreal, Quebec,
June 1, 2001
PDF version
(332 K)
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Deoxynucleic Guanidine (DNG), a positively charged
DNA analogue: Effect of modulating the overall positive
charge on DNG oligomers upon binding affinity and specificity
with complementary and mismatched DNA targets.
Oral presentation at the 218th American Chemical
Society National Meeting, New Orleans, Louisiana,
August 26, 1999
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Inclusion of Neutral Urea Linkages in Positively
Charged Deoxynucleic Guanidine (DNG) Oligomers. Synthesis
and Binding to Complementary DNA.
Poster presentation at the 81st Canadian Society
for Chemistry Conference & Exhibition, Whistler, British
Columbia, June 1, 1998
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Oligomeric deoxyribonucleic guanidine (DNG): A polycationic
analogue of DNA. Solid phase synthesis of purine and
pyrimidine DNG oligomers and fidelity studies.
Poster presentation at Cambridge Health Institute’s
Oligonucleotide Synthesis Conference, San Francisco,
California, June 24, 1998
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