Our cancer research, comparative pharmacogenetic and molecular toxicology research programs all involve clinical investigation of patients, human and veterinary, with adverse outcomes after exposure to drugs and chemicals. However, in addition to our major comparative pharmacology and toxicology research programs, we are involved in a number of clinical pharmacology studies on an on-going basis. Most of these studies are run in collaboration with other individuals at the Atlantic Veterinary College or other universities. Examples of current studies in which we are involved include:

• Clinical aspects of phenobarbital and potassium bromide toxicity in dogs (PI:    Dr. A. Cribb).
• Treatment of small airway inflammatory disease  in Standardbred Horses with Interferon alpha (PI: Dr. Ian Moore).
• Role of transforming growth factor beta in chronic renal failure and therapeutic interventions with ACE inhibitors (PI: Dr. Darcy Shaw).
• Comparative safety and efficacy of meloxicam, carprofen, and glucosamine in canine arthritis (PI: Dr. Jacque Dupuis, University of Montreal)

Gaskill C, Cribb A. Pancreatitis associated with potassium bromide/phenobarbital combination therapy in epileptic dogs. Can Vet J, 41: 555-558, 2000

Gaskill C, Burton S, Gelens H, Ihle S, Miller J, Shaw D, Brimacombe M, Cribb A. Changes in serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs receiving phenobarbital for one year. J Vet Pharmacol Ther, 23: 243-49, 2000

Gaskill C, Burton S, Gelens H, Ihle S, Miller J, Shaw D, Brimacombe M, Cribb A. Effects of phenobarbital on serum thyroxine and thyroid stimulating hormone in epileptic dogs. J Am Vet Med Assoc, 215: 489-496, 1999

Pfieffer E, Guy N, Cribb AE. Clomipramine-induced urinary retention in a cat. Can Vet J, 40: 265-67, 1999.

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