I. Refereed manuscripts:
1. Sawynok J., Sweeney M.I. and White T.D.. Classification of adenosine receptors mediating antinociception in the rat spinal cord. Br. J. Pharmacol. 88: 923-930, 1986.
2. Sweeney M.I. and Sawynok J.. Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation. Can. J. Physiol. Pharmacol. 64: 1324-1327, 1986.
3. Sweeney M.I., White T.D., K.H. Jhamandas and Sawynok J.. Morphine releases endogenous adenosine from the spinal cord in vivo. Eur. J. Pharmacol. 141: 169-170, 1987.
4. Sweeney M.I., White T.D. and Sawynok J.. Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. J. Pharmacol. Exp. Ther. 243: 657-665, 1987.
5. Sweeney M.I., White T. and Sawynok J.. 5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord. Brain Res. 462: 346-349, 1988.
6. Sweeney M.I., White T.D. and Sawynok J.. Morphine, capsaicin and K+ release purines from capsaicin-sensitive nerve terminals in the spinal cord. J. Pharmacol. Exp. Ther. 248: 447-454, 1989.
7. Sawynok J., Sweeney M.I. and White T.D.. Adenosine release may mediate spinal analgesia by morphine. Trends in Pharmacol. Sci. 10: 186-189, 1989.
8. Sawynok J. and Sweeney M.I.. The role of purines in nociception. Neurosci. 32: 557-569, 1989.
9. Sweeney M.I., White T.D. and Sawynok J.. 5-Hydroxytryptamine releases adenosine and cyclic AMP from primary afferent nerve terminals in the spinal cord in vivo. Brain Res. 528: 55-61, 1990.
10. Sawynok J., Sweeney M., Nicholson D. and White T.D.. Pertussis toxin inhibits morphine-induced adenosine release from the spinal cord. Prog. Clin. Biol. Res. 328: 397-400, 1990.
11. Sweeney M.I., White T.D. and Sawynok J.. Intracerebroventricular morphine releases adenosine and adenosine 3',5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism. J. Pharmacol. Exp. Ther. 259: 1013-1018, 1991.
12. Scott R.H., Sweeney M.I., Kobrinsky E.M., Pearson H.A., Timms G.H. , Pullar I.A., Wedley S. and Dolphin A.C.. Actions of arginine polyamine on voltage and ligand-activated whole cell currents recorded from cultured neurones. Br. J. Pharmacol. 106: 199-207, 1992.
13. Sweeney M.I. and Dolphin A.C.. 1,4-Dihydropyridines modulate GTP hydrolysis by Go in neuronal membranes. FEBS Lett. 310: 66-70, 1992.
14. Huston E., Cullen G., Sweeney M.I., Pearson H., Fazel M.S. and Dolphin A.C.. Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons. Neurosci. 52: 787-798, 1993.
15. Sweeney M.I., White T.D. and Sawynok J.. Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine. Brain Res. 614: 301-307, 1993.
16. Sweeney M.I.and Dolphin A.C.. Adenosine A1 agonists and the Ca2+ channel agonist Bay K 8644 produce a synergistic stimulation of the GTPase activity of Go in rat frontal cortical membranes. J. Neurochem. 64: 2034-2042, 1995.
17. Sweeney M.I., Yager J.Y., Walz W. and Juurlink B.H.J.. Cellular mechanisms involved in brain ischemia. Can. J. Physiol. Pharmacol. 73: 1525-1535, 1995.
18. Sweeney M.I.. Adenosine release and uptake in cerebellar granule neurons both occur via an inhibitor-sensitive equilibrative nucleoside carrier which is modulated by G-proteins. J. Neurochem. 67: 81-88, 1996.
19. Sweeney M.I. and Arneson D.S.. Desensitization of adenosine receptors during brain hypoxia limits the neuroprotective effects of adenosine. Can. J. Physiol. Pharmacol. 74: Axxxiv-xxxv, 1996.
20. Logan M. and Sweeney M.I.. Adenosine A1 receptor activation preferentially protects neurons versus astrocytes against hypoxia-induced cell death. Mol. Chem. Neuropathol. 31: 119-133, 1997.
21. Sweeney M.I.. Neuroprotective effects of adenosine in cerebral ischemia: window of opportunity. Neurosci. Biobehav. Rev. 21: 207-217, 1997.
22. Juurlink B.H.J. and Sweeney M.I.. Mechanisms that result in damage during and following cerebral ischemia. Neurosci. Biobehav. 21: 121-128, 1998.
23. Sweeney M.I. and Lyon, M.E. Selective effect of malathion on blood coagulation versus locomotor activity. J. Environ. Pathol. Toxicol. Oncol. 18: 203-211, 1999.
24. Sweeney M.I., Kalt W., MacKinnon S.L., Ashby J. and Gottschall-Pass K.T. Feeding of diets enriched in lowbush blueberries (Vaccinium angustifolium) for six weeks decreases stroke severity in rats. Nutritional Neuroscience 5: 427-431, 2002.
25. Matchett, M.D., MacKinnon, S.L., Sweeney, M.I., Gottschall-Pass, K.T., and Hurta, R.A.R. Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells. Biochem Cell Biol. 83: 637-643, 2005.
26. Matchett, M.D., MacKinnon, S.L., Sweeney, M.I., Gottschall-Pass, K.T., and Hurta, R.A.R. Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. J. Nutr. Biochem. 17: 117-125, 2006 [Epub Aug 17, 2005].
27. Neto, C.C., Krueger, C.G., Lamoureaux, T.L., Kondo, M., Vaisberg, A.J., Hurta, R.A.R., Curtis, S., Matchett, M.D., Yeung, H., Sweeney, M.I., Reed, J.D. MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro. J. Sci. Food Agric. 86: 18-25, 2006 [Epub Oct 17, 2005].
28. Slemmer, J.E.., Shacka, J.J., Sweeney, M.I. and Weber, J.T. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr. Med. Chem. 15 (4): 404 - 414, 2008.
II. Book chapters and expositions, refereed:
1. Sawynok J., Nicholson D.J., Sweeney M.I. and White T.D.. Adenosine release by morphine and spinal antinociception: role of G proteins and cyclic AMP. NIDA Res. Monogr. 105: 40-46, 1991.
2. Dolphin A.C., Huston E., Pearson H., Menon-Johansson A., Sweeney M.I., Adams M.E. and Scott R.H.. G protein modulation of calcium entry and transmitter release. Annals N.Y. Acad. Sci. 635: 139-152, 1991.
3. Dolphin A.C., Menon-Johansson A., Campbell V., Berrow N. and Sweeney M.I.. Modulation of voltage-dependent calcium channels by GABAB receptors and G-proteins in cultured rat dorsal root ganglion neurons: relevance to transmitter release and its modulation. In Cellular mechanisms of sensory processing: The somatosensory system. (L. Urban, ed.), Springer-Verlag, Heidelberg. pp. 47-61, 1994.
4. Sweeney M.I.. Measurement of the GTPase activity of signal-transducing G-proteins in neuronal membranes. In Methods in Molecular Biology, Vol. 41: Signal Transduction Protocols (D.A.Kendall & S.J. Hill, eds.), Humana Press, New Jersey. pp. 51-61, 1995.
5. Sweeney M.I. Adenosine A1 receptors inhibit necrosis and apoptosis induced by oxygen and glucose deprivation in cultured neurons. Annals of the NY Academy of Sciences Conference entitled “Oxidative/Energy metabolism in neurodegenerative disorders” 2000.
6. Neto, C. C., Sweeney-Nixon, M. I., Lamoureaux, T. L., Soloman, F, Kondo, M., MacKinnon, S. L. Cranberry phenolics: Effects on oxidative processes, neuron cell death and tumor cell growth. In Phenolic Compounds in Foods and Natural Health Products, American Chemical Society Symposium Series 909 (Shahidi F. and Ho C.-T., eds), pp. 271-282, 2005.
7. Sweeney M.I. Pomegranate juice consumption reduces simulated ischemic stroke damage and increases brain antioxidant status in rats. In “Pomegranate: Ancient Roots to Modern Medicine”, (N. Seeram, R. Schulman and D. Heber, eds.), CRC Press, pp. 91-106, 2006.
III. Abstracts and conference presentations:
1. Sweeney M., White T. and Sawynok J.. Characterization of adenosine receptors producing antinociception following intrathecal injection. Proceedings of the Can. Fed. Biol. Sci. 29: 112, 1986.
2. Sweeney M.I., White T.D. and Sawynok J.. Involvement of adenosine in the analgesic effect of morphine and noradrenaline in the spinal cord. Soc. Neurosci. Abstracts 12: 1018, 1986.
3. Sweeney M.I., White T.D. and Sawynok J.. Effect of intrathecal pretreatment with neurotoxins on adenosine release from rat spinal cord synaptosomes. Soc. Neurosci. Abstracts 13: 1388, 1987.
4. Sweeney M.I., White T.D. and Sawynok J.. Morphine releases adenosine from capsaicin-sensitive neurons in the spinal cord. Proceedings of the Can. Fed. Biol. Sci. 31: 80, 1988.
5. Sweeney M.I., White T.D. and Sawynok J.. Serotonin releases adenosine from primary afferent nerve terminals in the spinal cord: possible involvement in spinal antinociception. Soc. Neurosci. Abstracts 14: 852, 1988.
6. Sweeney M.I., White T.D. and Sawynok J.. Morphine-evoked release of adenosine from the spinal cord occurs via a dipyridamole-sensitive carrier. J. Neurochem. (Suppl.) 52: S99B, 1989.
7. Sweeney M.I., White T.D. and Sawynok J.. Adenosine, but not its phosphorylated nucleotides, is released from the spinal cord via a dipyridamole-sensitive carrier. In Adenosine Receptors in the Nervous System, ed. J.A. Ribeiro, Taylor and Francis (London): 213, 1989.
8. Sweeney M.I., White T.D. and Sawynok J.. Adenosine release from the spinal cord may mediate antinociception by intracerebroventricular morphine. Soc. Neurosci. Abstracts 15: 371, 1989.
9. Sweeney M.I., White T.D. and Sawynok J.. Intracerebroventricular morphine releases cyclic AMP and adenosine from the spinal cord via a serotonergic mechanism. Eur. J. Pharmacol. 183: 1450-1451, 1990.
10. Sweeney M.I., and Dolphin A.C.. Biochemical evidence that dihydropyridine and GABAB receptors interact with Go and Gi respectively. Soc. Neurosci. Abstracts 17: 68, 1991.
11. Sweeney M.I. and Dolphin A.C.. Biochemical evidence that GTP binding proteins are directly coupled to dihydropyridine receptors. Proceedings of the Eur. Neurosci. Assoc., abstract # 1047, 1991.
12. Sweeney M.I. and Dolphin A.C.. The GABAB receptor agonist (-)-baclofen and the 1,4-dihydropyridine Ca2+ channel agonist Bay K 8644 modulate the GTP-binding protein Go via different mechanisms. Br. J. Pharmacol. (Suppl.) 107: 240P, 1992.
13. Sweeney M.I. and Dolphin A.C.. Adenosine A1 agonists stimulate the GTPase activity of Gi- and Go-type G-proteins in cortical membranes: synergism with Bay K 8644. J. Neurochem. (Suppl.) 61: S78D, 1993.
14. Sweeney M.I.. Activation of adenosine receptors protects neurons from ischemia-induced death. Soc. Neurosci. Abstracts 20: 1042, 1994.
15. Sweeney M.I. and M. Logan. Endogenous adenosine protects neurons but not astrocytes from hypoxic cell death. Proceedings of the Can. Fed. Biol. Soc. 38: 58, 1995.
16. Sweeney M.I., Arneson D.S. and Murton A. Adenosine A1 receptor agonists prevent delayed neuronal death following ischemia. Soc. Neurosci. Abstracts 22: 1433, 1996.
17. Sweeney M.I. and Arneson D.S. The adenosine agonist CPA inhibits necrosis but promotes apoptosis induced by simulated ischemia in neuronal cultures. Soc. Neurosci. Abstracts 23: 1924, 1997.
18. Sweeney M.I. and Campbell, D.S. Adenosine A1 receptors precondition the rat brain against hypoxia-ischemia damage one day later. Soc. Neurosci. Abstracts 25: 2051, 1999.
19. Rigley S.T., Sweeney M.I. and R.A.R. Tasker. Cyclopentyladenosine decreases apoptotic cell death in cerebellar granule neurons after oxygen-glucose deprivation. Soc. Neurosci. Abstracts 26: 2067, 2000.
20. Campbell D.S. and Sweeney M.I. . Adenosine agonist reduces hypoxia-ischemia induced cell death in the hippocampus of male rats. Soc. Neurosci. Abstracts 26: 508, 2000.
21. Sweeney-Nixon, M., Blacquiere, D., Ashby, J., MacKinnon, S., Kalt, W. & Gottschall-Pass, K.. Short term diets enriched with wild blueberries decrease stroke severity in rats. Proc of the Can. Fed. Biol. Soc. 44: 56, 2001.
22. Gottschall-Pass, K., Rogers, L., Ashby, J., MacKinnon, S., Kalt, W., Sweeney-Nixon, M.. Wild blueberry extracts produce modest improvements in predictors of cardiovascular disease in cholesterol fed rabbits. Proceedings of the Can. Fed. Biol. Soc. 44: 57, 2001.
23. Sweeney M.I., K.J. Clark, S. MacKinnon, W. Kalt and K.T. Gottschall-Pass. The effects of individual fractions of lowbush (wild) blueberries (Vaccinium angustifolium) on primary cultured neurons after simulated ischemic stroke and oxidative stress. PEI Health Research Institute Forum (May 2002).
24. Sweeney M.I., Rigley S.T., Campbell D.S. and Tasker R.A.R. A1-adenosine receptor activation several hours before stroke decreases necrotic and apoptotic death in vitro and in vivo. Soc. Neurosci. Abstracts 28: 2002.
25. Dunsford, C., Sweeney M.I., and Gottschall-Pass, K.T. Lowbush blueberry consumption reduces atherosclerotic plaque size in hypercholesterolemic rabbits. Proceedings of the Can. Fed. Biol. Soc. 46: 64, 2003.
26. Sweeney M.I., Soloman F. and Neto, C.C. Antioxidant rich fractions isolated from cranberries reduce neuronal death in response to simulated ischemic stroke and reperfusion injury in vitro. Proceedings of the Can. Fed. Biol. Soc. 46: 92, 2003.
27. Sweeney M.I., Gottschall-Pass, K.T., Clark , K.J. and Durant, C. Anthocyanins Isolated from Lowbush Blueberries (Vaccinium Angustifolium) Inhibit Oxidative Stress-induced Nitrite Accumulation and NOS Induction in Cultured Cerebellar Granule Neurons. (Presented at Experimental Biology ‘04, Washington, DC) 2004.
28. Gottschall-Pass, K., Macdonald, K., Garrity, E., Pass, E., LeClair-Morrison, S. & Sweeney, MI. Extracts from wild blueberries (Vaccinium angustifolium) reduce markers of LPS-induced inflammation in the rat. (Presented at Experimental Biology ‘05, San Diego, CA), 2005.
29. Sweeney M.I., Harmon, M.I., Durant, C.D., Soloman, F. and Schulman, R.N. Pomegranate juice consumption reduces simulated ischemic stroke damage and increases brain antioxidant status in rats. (Presented at Experimental Biology ‘05, San Diego, CA), 2005.
30. M. Sweeney, K. Shaughnessy, K. Gottschall-Pass. Blueberry diets delay the onset of hypertension and reduce insulin resistance in spontaneously hypertensive stroke prone rats. FASEB J. 21(6): A1092, 2007.
31. K. Shaughnessy, M. Sweeney, and C. Neto . Investigation of the effects of cranberry fractions on atherosclerosis in mice. FASEB J. 21(6): A1093, 2007.
32. K. Gottschall-Pass, M. Wark, H. Yeung, E. Pass, S. Purcell, R. MacPhee & M.I. Sweeney. Blueberry supplementation lowers iNOS but not COX-2 expression in LPS challenged rats. FASEB J. 21(6): A36, 2007.
Department of Biology